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The compound was developed from work on Epithalamin, a mixture of low-molecular-weight peptides extracted from bovine pineal tissue
Current protocols recommend treating patients with an initial dose of 150 mg/kg NAC, infused over a period of an hour, upon hospitalization, followed by decreasing amounts of NAC infused over the next 20 hours
Caputo R, Buono G, Piezzo M, Martinelli C, Cianniello D, Rizzo A, et al
Caffeine does not increase the risk of atrial fibrillation: a systematic review and meta-analysis of observational studies
Another challenge for nose-to-brain drug delivery is the development of appropriate delivery devices, since standard devices are optimized for local effects and therefore deliver only a small amount of drug to the olfactory region [65]
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