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Levels naturally decline with age, stress, poor diet, and toxin exposure, which may impact skin health, immunity, and cellular aging

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The peptide promotes angiogenesis at 1 nanomolar concentration through VEGF and bFGF expression, improving blood vessel formation and microcirculation in damaged tissue

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The complete selection process, including the number of records identified, screened, and excluded with explicit reasons (separated for preclinical and clinical/epidemiological literature), is documented in the PRISMA flow diagram (Figure 1)