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Skouta et al., 2014

When to call your provider Within 3-5 days: No bowel movement for 5+ days despite using Miralax or other osmotic laxative Severe abdominal pain or distension Inability to pass gas Vomiting, especially if it tastes or smells fecal Within 1-2 weeks: Constipation not improving after 2 weeks of consistent dietary changes plus Miralax Blood in stool (bright red or dark/tarry) Severe pain during bowel movements Unintended weight loss beyond expected from the medication At your next scheduled visit: Mild persistent constipation that's manageable but bothersome Questions about whether to escalate dose given current constipation Interest in prescription motility agents The threshold for calling is lower if you have a history of bowel obstruction, diverticulitis, inflammatory bowel disease, or prior abdominal surgery

GLP-1 also acts on receptors in your brain to reduce hunger cues, which can lower appetite and overall calorie intake

In the population of patients who were overweight or obese, 20 NAION events occurred in the prescribed semaglutide cohort vs 3 in the nonGLP-1 RA cohort

Keep the vial sealed at all times when not in use