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Dose reduction remains the most reliable solution if water retention becomes genuinely bothersome
The CNS GLP- 1 receptors are not necessary for the physiological regulation of blood glucose levels by endogenous GLP- 1 or the pharmacological control of glucose homeostasis that depends on GLP- 1 receptors, although further research is needed to investigate the possible role of GLP- 1 receptors expressed outside the beta cell, including within the enteric and peripheral nervous systems, in improving beta cell function through enteral glucose mediation [70, 84]
Animals were housed under standard vivarium conditions with free access to food and water under a 12-hour light/dark cycle
Single-pathway GLP-1 medications transformed weight care, but tirzepatides dual mechanism appears to push results further
10.1152/ajpendo.00422.2013 14 LaiL.LeoneT
