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By activating GIP receptors, tirzepatide enhances insulin secretion in a glucose-dependent manner, meaning insulin release occurs primarily when blood glucose levels are elevated, thereby reducing the risk of hypoglycemia
Indefinitely, under physician supervision weight regain is common when patients stop
Marx N, Husain M, Lehrke M, Verma S, Sattar N (2022) GLP-1 receptor agonists for the reduction of atherosclerotic cardiovascular risk in patients with type 2 diabetes
Other tissue-specific alterations were detected, including distinct effects on hepatic and renal one-carbon metabolism, as well as region specific differences in metabolism across hippocampal and cortical parts of the brain