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Br J Pharmacol 177(8):18061821 Li ZY, Wu G, Qiu C, Zhou ZJ, Wang YP, Song GH, Xiao C, Zhang X, Deng GL, Wang RT, Yang YL (2022) Mechanism and therapeutic strategy of hepatic TM6SF2-deficient non-alcoholic fatty liver diseases via in vivo and in vitro experiments

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The BPC 157-enhanced cell migration was completely suppressed in the presence of 50 nM hemoglobin, suggesting that the amount of nitric oxide produced by 1.0 g/ml BPC 157 did not exceed 200 nM because hemoglobin contains four heme groups in each molecule

Careful explanation was sufficient reassurance that there would be no untoward effects

Most drug candidates are in clinical development (45 out of 67, 67%) which is an encouraging sign that investment in basic research has paid off, uncovering therapeutic avenues now being actively pursued