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Water retention and mild joint stiffness are common at 25 mg

For UK-based researchers running parallel tendon, ligament or muscle models, that reduction in pipetting and labelling steps is the practical case for the format

Acknowledgements Special thanks for all study team for their dedication and support in this study

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The requirements of potential nanocarriers for CNS drug delivery are biodegradability, non-toxic characteristics, scalable synthesis and controlled loading or coupling with hydrophilic or hydrophobic drugs [20, 21]