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When fragmental coupling is used, the synthesis yield of the crude peptide is 93%, the purity of the crude peptide is 72.4%, the purification yield is 34.4% and the purity of the refined peptide is 99.60%
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Initial concerns were raised by an early, methodologically critiqued study and a series of case reports in which the majority of severe ocular complications presented as NAION [114, 115]
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