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[8] [9] Common Gastrointestinal Side Effects Explained Nausea, diarrhoea, vomiting, and constipation are the most common gastrointestinal side effects of retatrutide, reported in up to 60% of Phase 2 trial participants and increasing with higher doses

To minimize the risk and intensity of gastrointestinal side effects, it is recommended to start with a low dose of semaglutide and gradually increase the dosage