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This tells the pituitary to release a growth hormone pulse, which then drives downstream effects: IGF-1 production, muscle protein synthesis, fat mobilisation, and tissue repair
In addition, it has been suggested that activation of TLR4 plays a substantial role in the upregulation of placental oxidative stress in other models of placental insufficiency, such as preeclampsia [43, 45]
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doi: 10.3390/ijms20071584 50 ItohAIrieJTagawaHKusumotoYKatoMKobayashiNet al
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