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Benefits of GLP-1 Agonists in MASH Histologic Improvements Studies have shown that treatment with GLP-1 agonists can lead to a reduction in liver inflammation and fibrosis, and hence result in an improvement in the overall structure of liver tissue1

Our findings support this hypothesis, as increases in vitamin D and reductions in cortisol and CRP persisted after weight adjustment, whereas changes in glucose, HbA1c, insulin, HOMA-IR, HDL, and other metabolic markers appeared to be predominantly mediated by weight loss.12,28,29 In 2017, the first case was published describing a patient with refractory HS, obesity, and type 2 diabetes who experienced improvement in dermatologic lesions following treatment with liraglutide.19 Subsequent prospective case series further explored this therapeutic strategy, although these cohorts consistently included patients with type 2 diabetes, and liraglutide doses were therefore lower than those approved for obesity management

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n = 71 cells, 4 slices, 3 male mice)

Synthesized in the liver and present in every cell, it is involved in detoxification, immune function, and maintaining cellular integrity