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It reflects the biological reality that the medication was managing a chronic condition, and removing it allows the condition to reassert itself

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1e): 3,9,14,15,30,34,46,57,60 (i) The thiolate of the reduced monothiol class I glutaredoxin directly attacks the disulfide substrate followed by the stepwise reduction of the mixed disulfide and Grx(SSG) by two molecules of GSH

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