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Anti-inflammatory mechanisms via attenuation of neutrophil activation were demonstrated by Dokken et al

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Animal model studies have suggested that GLP-1RAs may cause pancreatitis and exocrine dysplasia, but in the large RCTs and a meta-analysis, GLP-1RAs did not increase the risk of pancreatitis or pancreatic cancer [82,83]

Long-term human data are still limited, and they are not FDA-approved for pain.