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Given the ongoing opioid crisis, a peptide that could ease withdrawal without the addictive potential of other therapies would fill a meaningful clinical gap

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Orforglipron's lower manufacturing costs, room-temperature stability, and oral formulation could make effective obesity pharmacotherapy accessible to populations in low- and middle-income countries for the first time, representing a significant advance in global health equity

Thats also why they should not be used together both act through the same incretin pathway, and combining them adds cost and complexity without added clinical benefit

HHD is a chronic condition marked by recurrent flare-ups and limited treatment options [41]