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Research has found that exposing renal tubular epithelial cells to various concentrations of CaOx crystal solution results in a significant increase in the expression of ferroptosis-related proteins such as p53, ACSL4, transferrin receptor (TRC), and TF as the concentration of CaOx crystals increases
7.2 Ferroptotic cells program macrophage mobilization Many clinical diseases cause ferroptotic cell death, and macrophages are the primary effectors in ferroptotic cell clearance
Additionally, the construction of proteinprotein interaction (PPI) networks has further enhanced target screening capabilities
However, peptides are inherently unstable in aqueous solutions, susceptible to hydrolysis, aggregation, oxidation, and deamidation, making formulation critical for stability
Zhu F, Yan P, Zhang J, Cui Y, Zheng M, Cheng Y, Guo Y, Yang X, Guo X, Zhu H (2019) Deficiency of TPPP2, a factor linked to oligoasthenozoospermia, causes subfertility in male mice
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