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Resident-intruder paradigm In this experiment, mice that had been socially isolated, each living alone in its own cage for four weeks, were brought into the testing room one by one

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A low intake of folate leads to an increased demand for choline-derived metabolite, betaine

As regards the pathogenic mechanisms, the occurrence of an oxidant stress (resulting from an impaired homocysteine metabolism, which modifies the redox status of extra- and intracellular thiols and thus alters the intracellular redox potential) might play a central role in moderate hyperhomocysteinemia-mediated vascular disorders