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2.1 Anti-inflammatory signaling and antioxidant effect Low-grade vascular inflammation is a central driver of atherogenesis, promoting monocyte recruitment, cytokine secretion, and plaque progression ( 2.2 Improvement of endothelial function and reduction of adhesion molecules Endothelial activation is an early biochemical event in atherosclerosis, characterized by increased expression of adhesion molecules, including Intercellular Adhesion Molecule 1 (ICAM-1), vascular Cell Adhesion Molecule 1 (VCAM-1), Monocyte Chemoattractant Protein-1 (MCP-1), and L-selectin
Side effects are rare but can include mild discomfort at the injection site or a slight rash
Cigna may cover Zepbound for obstructive sleep apnea with prior authorization if other treatment methods have been ineffective
The final iteration was to apply a rule that checked that new triangles were not outside the existing region (as determined by planes formed by triangles with a concave edge), while allowing for slightly concave edges, in addition to earlier rules
