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Part of it is justifying the contrarian position with these short term trials because then you could dunk on people and get attention

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MOTS-c acts largely through AMPK, an energy-sensing pathway, and no receptor desensitization or tolerance problem has been established for it the way it has for growth hormone secretagogues

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[PMID: 16461014] Laboratory literature summary: Is fluoroacetate-specific defluorinase a glutathione S-transferase