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There is an association between patients who carry the HLA-DQA1*05 gene and development of antibodies against anti-TNF agents[83]

PloS One (2011) 6(7):e21772

That distinction matters for long-term sleep quality, morning alertness, and the overnight recovery processes (GH release, tissue repair, immune function) that depend on genuine deep sleep

Some protocols extend to 8-12 weeks with longer off periods