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A small study found that men with GSTT1 null genotypes were at an 11-fold increased risk of Parkinsons with paraquat exposure.[ref] This ties together with MAO-B the GST enzymes help combat the oxidative stress from high H2O2 levels due to MAO-B expression
PLoS ONE 3 , e2853 (2008)
On the other hand, disturbances observed in the course of depression do not clearly indicate whether they are the effects of disruption of metabolic processes in the brain
doi: 10.1146/annurev-genom-083115-022438 105 KohlerS.ThomasA
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