Diet-induced alterations in gut microbial composition and the products generated by the microbiota affect immune-mediated neurological conditions including developmental disorder, neurodegenerative disorder, and emotional dysregulation (Ma et al., 2019) Omics approaches have furthered knowledge of the gut microbiota as a central mediator of the gut-brain axis (Lee et al., 2011)
Animal studies indicate dose-dependent effects, with toxic doses possibly affecting copper metabolism or interacting with embryonic development in hypersensitive models, warranting caution during pregnancy
We also examined the role of glycosylation by introducing asparagine-to-alanine substitutions at six different potential N -glycosylation sites in surface-targeted LacAnc100, none of which appeared to notably reduce its activity (Supplementary Fig
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