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Site Rotation Rotate injection sites systematically to prevent soreness, lipohypertrophy, or scar tissue buildup [18]

In clinical trials, the results are modest but real

The recommended approach is to try conservative management strategies first (cool compresses, antihistamines, clothing changes), then consider dose adjustment if symptoms persist beyond 4 weeks, and only discuss discontinuation if symptoms are severe and unresponsive to other interventions

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