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By encapsulating drug molecules in nanoparticles, nanoparticle drug delivery systems exhibit the advantage of improved drug loading, less exposure of the drug molecule to metabolic enzymes and drug efflux pumps, longer blood circulation, and facilitation of drug passage through the cell membrane via transcytosis instead of passive diffusion

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This allows it to cross cell membranes intact, where it is converted into active glutathione inside the cell

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the toxic effects of SSRIs on the mechanism of toxic effects of SSRIs on the reproductive system has not been fully clarified, and although some studies have explored mechanisms such as oxidative stress, changes in hormone levels, and apoptosis, they lack systematic and in-depth nature, and lack in vivo model validation