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A 2024 Reuters analysis by Prime Therapeutics (a large PBM) reported that in the first two years after introduction, patients on weight-loss GLP-1s actually had higher total annual healthcare costs than matched controls (driven by drug costs and some medical utilization) ( [42] )
Selectivity was reported against COMT and against the SAM-dependent DNA and protein methyltransferases DNMT1 and PRMT3
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