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3 Effects of GWAS index SNPs in the vicinity of GLP1R locus on efficacy and side effects, partitioned by drug type

The SELECT cardiovascular outcomes trial established that semaglutide reduces major adverse cardiovascular events by 20%, providing a strong clinical rationale for treatment that extends beyond weight management alone

However, they are associated with several common side effects, primarily affecting the gastrointestinal system

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The two medications work through different pathways, so they complement each other without direct interactions