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This phenomenon is independent of DPP-IV, the GLP-1 receptor, or the PYY related peptide NPY

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Apr 16 2021;13(4)doi:10.3390/nu13041317 Lu K, Yip YM

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Details of the National Institutes of Health-funded study were published this week in a Nature paper titled A brain reward circuit inhibited by next-generation weight-loss drugs in mice. In it, the team reported that they investigated the small-molecule GLP-1s including Eli Lillys recently approved drug orforglipron, also known by the brand name Foundayo, as well as danuglipron, an oral GLP-1 that was being developed by Pfizer until the company decided to discontinue its development in 2025