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Fat cells release inflammatory mediators known as adipokines , including: Leptin Adiponectin Interleukin-6 Tumor necrosis factor-alpha These mediators contribute to: Cartilage degradation Synovial inflammation Osteophyte formation Because of these mechanisms, obesity is considered one of the most important modifiable risk factors for knee osteoarthritis

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Van Den Boorn JG, Konijnenberg D, Dellemijn TA, Van Der Veen JW, Bos JD, Melief CJ, Vyth-Dreese FA, Luiten RM