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Description

First, the -ECS catalyzes the formation of an intermediate product -glutamylcysteine (-EC) and acts as a ligase between the amino acid glutamate and cysteine

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The nuclear factor-kappa B pathway has long been considered a prototypical proinflammatory signaling pathway, largely based on the role of NF-B in the expression of proinflammatory genes including cytokines, chemokines, and adhesion molecules 20

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2007 Dec;144(6):825-30

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