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Therapeutic TMS is relatively new so long-term side effects, if any, are unknown

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However, its efficacy and duration depend on the number of cardiomyocytes transduced

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Potential endpoints include: Matrix metalloproteinase expression Enzyme activity Tissue inhibitor expression Substrate cleavage Matrix degradation Balance between synthesis and turnover Cell-specific secretion Time-dependent pathway changes Matrix remodeling is not inherently beneficial

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