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In a systematic review of weight loss and imaging outcomes in overweight or obese individuals with hip or knee OA, Daugaard and colleagues concluded that there was no consistent evidence that weight loss altered structural OA pathology, while also emphasizing major heterogeneity in the structural endpoints used across studies ( 8 Future directions 8.1 Trials must move beyond pain endpoints toward pathway-relevant outcomes The next-generation of studies in obesity-related KOA should not be limited to short-term symptom endpoints

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concluded that a return to baseline gastric function would not occur until discontinuation of the GLP-1 RA for at least five half-lives prior to a procedure, whereas Midler et al

4b), confirming the results shown in Fig