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Fumarate subsequently spatially translocates into the nucleocytosolic compartment, where it acts as a competitive inhibitor of nuclear KDM5 family histone demethylases to stable maintaining the activation of epigenetic marks (H3K4me3) at pro-inflammatory gene promoters
The same principles that apply to peptide delivery generally apply to GLP-1 delivery specifically
Although promising, most of the published studies have been in animal models rather than large-scale human clinical trials
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