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Epididymal fat was subjected to haematoxylin and eosin (H&E) staining, immunohistochemical (IHC) staining, TG and glycerol content per cell, and SIRT1 activity assay (see ESM Methods)
Survival in gastric conditions is necessary for oral activity but not sufficient systemic oral bioavailability additionally requires intestinal absorption across the epithelium, survival of first-pass metabolism, and distribution to target tissue, none of which have been characterised for BPC-157
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In parallel, emerging data from male reproductive studies suggest that GLP-1RAs may positively influence the hypothalamic-pituitarytesticular axis, improve testicular function, and enhance spermatogenesis, particularly in obese men
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