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Mutations in ALS-related genes interfere with mitochondrial functioning that leads to problems in energy production, increased oxidative stress, and abnormal mitochondrial axonal transport (Table 2)
Macro-B12 should be suspected when a markedly high value persists with no B12 exposure, sits with an unrevealing workup, and disagrees with functional markers
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a very tiny protein that included three amino acids: cysteine, glycine, and glutamic acid
