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However, you should contact your healthcare provider if: Your fatigue is severe or debilitating Tiredness doesn't improve after several weeks You experience other concerning symptoms alongside fatigue You become so tired that you cannot perform daily activities These could indicate more serious issues like severe dehydration or another underlying condition that needs attention

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In turn, nausea is the main adverse event associated with GLP-1RAs class

That conversation rules out interactions and risk factors most patients have no reason to know about

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