rebound weight gain after semaglutide stopping or tirzepatide is real, but it's not because the body is “damaged”—it reflects how the body adapts after weight loss. When the medication is stopped, hunger Weight loss from GLP 1

In the randomized STEP 2 trial (intent to treat: 1,210 adults with overweight or obesity and T2D), the estimated treatment difference from baseline to week 68 for semaglutide 2.4 mg versus placebo was 6.2 percentage points (95% CI 7.3, 5.2

has taken a GLP-1 drug to treat diabetes, promote weight loss or prevent heart attacks or strokes (in those with a history of heart disease)

Learn more about bariatric surgery side effects

Some studies have evidenced that hyperinsulinemia may activate the renin-angiotensin system, increase sympathetic nervous system activity and renal sodium retention and, if sustained, all these elements could increase blood pressure (112, 114)

This is particularly relevant for time-sensitive medicines