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As IAP antagonists induce the degradation of IAP proteins such as cIAP1/2 and can inhibit the activity of XIAP [50], we hypothesised that combination treatment of b-AP15 and IAP antagonists may be synergistic in HNSCC cells

LaRocca TJ, Sosunov SA, Shakerley NL, Ten VS, Ratner AJ

The move comes after the FDA approved Wegovy (semaglutide) for weight management in adults in 2021

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Two estimands were employed: the trial product estimand, which evaluated treatment effects assuming perfect adherence to the assigned regimen, and the treatment policy estimand, which included all randomized participants regardless of adherence