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MSC-focused analyses report improvements in neurological deficits and activities of daily living [46,47,48,49,50], whereas the Cochrane review emphasizes uncertainty and the need for larger, well-controlled trials [47]

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Although SUMMIT also demonstrated a reduction in the composite endpoint of cardiovascular death or worsening HF events, the magnitude of the improvement, specifically in the KCCQ-CSS observed with higher-dose semaglutide (STEP-HFpEF

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