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We conducted a wide range of additional control experiments to make sure we were looking at a true Orai1 deficiency phenotype. The investigators also created genetically modified mice that lacked Orai1 channels in excitatory neurons, but retained them elsewhere in the body and the brain
Monitoring temperature changes and discussing any concerns with a healthcare provider ensures that the medications benefits outweigh any potential side effects
It means the comparison should separate what trials suggest from what clinicians can prescribe and monitor today
NRF2 activation promotes the recurrence of dormant tumour cells through regulation of redox and nucleotide metabolism
doi:10.1038/nrendo.2012.140 7
