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Semaglutide produced less weight loss than tirzepatide head-to-head, about 14% versus 20%. Its body-composition substudy measured a roughly 62:38 fat-to-lean loss split by mass, compared with about 75:25 for tirzepatide in a separate trial. The scan overstates muscle loss because lean mass includes water and organ tissue

Efficacy : Some studies indicate it may lead to greater weight loss than Semaglutide, with average losses around 20% in clinical trials

However, the use of synthetic growth hormone comes with several drawbacks

Wegovy (semaglutide 2.4 mg) and Zepbound (tirzepatide) are both FDA-approved specifically for weight management in adults with obesity or overweight with a weight-related condition regardless of whether diabetes is present

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