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Phase III and large retrospective analyses consistently report a significant reduction in incidence of symptomatic cardiotoxicity with PLD, yet survival benefits remain modest and toxicity simply shifts toward mucocutaneous adverse effects such as palmarplantar erythrodysesthesia and stomatitis [212]

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These risks are low, but they are the reason staying hydrated, losing weight at a steady pace, and paying attention to persistent or severe symptoms all matter

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