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Under diabetic conditions, phagocytosis of apoptotic -cells by macrophages generates ROS, leading to inflammasome activation, and the secretion of pro-inflammatory cytokines (notably IL-1 ), all hallmarks of an M1-like phenotype (60)
J aagric biol sci
Reconstitution in 0.1% acetic acid (10 mM) is common practice, as the peptide tends to aggregate in neutral aqueous solutions without an acidifying agent
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While sublingual and oral spray formulations are available, there is no robust evidence that they offer superior absorption compared to standard oral tablets
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